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By Dr. rer. nat. Dr. med. habil. Hubert Korr (auth.)
Studies on cellphone kinetics in untreated animals have for the main half been performed on or gans within which many proliferating cells are available. commonly the proliferating cells were pointed out both in histologic sections as mitoses or by means of autoradiography as classified interphase cells following the injection of a categorised precursor of DNA, comparable to 3H_ or 14C-thymidine (TdR). a very good many proliferating cells could be saw within the rat and mouse mind through the embryonic interval and for a short while after delivery, and plenty of stories on cellphone kinetics were played for this section of lifestyles. in contrast, only a few proliferating cells are present in the mind of grownup rodents (except for the subependymallayer, see below). for that reason, basically remoted stories were performed on mobilephone kinetics in this interval. Al even though there's a rise in proliferating cells in grownup animals which were pre taken care of (e g. , by way of wounding, X-irradiation, viral an infection, withdrawal of water), this proliferation too has now not been investigated intimately. a couple of reports were performed when you consider that 1959 at the proliferation of cells within the sub ependymal layer of the lateral ventricles of the forebrain. This phone sort is definitely fitted to such investigations simply because mitoses are available there even in animals that are particularly previous. because the experiences ofLe blond and associates (Walker and Leblond 1958 ;Messier et al.
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Extra resources for Proliferation of Different Cell Types in the Brain
If the experimental values in Fig. 3 are compared with theoretical curves constructed under the assumption of Te = 15 h or Te = 25 h, large discrepancies arise. This shows that the glial cells in the investigated brain regions of 14-day-old rats proliferate with T e of approximately 20 h. 4 Double-Labeling Methods with 3H_ and 14C-TdR Before discussing double-labeling methods with 3H- and 14C-TdR for the determination of T s and Tc' we shall first describe the basic technique for evaluating such experiments: namely the two emulsion layer autoradiography.
But available histometric data on changes in glial cell density with age (Brizzee et al. 1964; Ling and Le blond 1973; Bayer 1977) indicate that this is not the case. , passes into the nongrowth fraction. Thus, all considerations point to the fact that the glial cells undergo a steady state growth in the brain of adult mice. These considerations can also be confirmed experimentally: Following a single injection of 3H-TdR or 14C-TdR, a great many labeled glial cells were found 6,8 or 14 days later (Korr 1978a).
Under this assumption (shown by the dotted line in Fig. 7) the value of v remains constant during the next 10 h (during which time the cells pass through the S phase), and thereafter increases again when the group of purely 3H-labeled cells undergoes the second mitosis after labeling. As mentioned earlier, an additional injection of 14C-TdR influences the group of purely 3H-labeled cells, and thus the value of v, only if these cells are in the S phase. For a measured TS of 10 h and measured TG 2 +M of 4 h, and an assumed cycle time TC = 20 h, this is the case in the interval between t = 10 hand t = 24 h.
Proliferation of Different Cell Types in the Brain by Dr. rer. nat. Dr. med. habil. Hubert Korr (auth.)