New PDF release: Advances in Immunology, Vol. 32
By Frank J. (Editor) Dixon
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Extra info for Advances in Immunology, Vol. 32
Prosuppressor, suppressor inducer, suppressor effector) that is disordered when an abnormality in the suppressor T-cell network is demonstrated in coculture studies of patient and normal cells stimulated with PWM. VI. Regulatory Role of Circulating Monocytes in B-Cell Activation by Polyclonal Stimulators A. A monocyte requirement for an optimal immune response has been suggested for the in vitro antibody responses of mice to a number of antigens and for the proliferation of murine lymphocytes to mitogens and antigens (Mosier, 1967; Shortman and Palmer, 1971).
VI. Regulatory Role of Circulating Monocytes in B-Cell Activation by Polyclonal Stimulators A. A monocyte requirement for an optimal immune response has been suggested for the in vitro antibody responses of mice to a number of antigens and for the proliferation of murine lymphocytes to mitogens and antigens (Mosier, 1967; Shortman and Palmer, 1971). Similarly, human lymphocytes have been 30 THOMAS A. , 1968; Alter and Bach, 1970). , 1977). However, more recently it has been shown that there is a monocyte dependence for the proliferation and differentiation of human B cells that is induced by some of the polyclonal B-cell activators, including PWM.
WALDMANN AND SAMUEL BRODER ity. Other T-cell-dependent activators, such as SLO, SPL, SPA, WGA described in this review can also be used in similar coculture studies that involve patient’s T cells and normal B cells to assess antigen nonspecific-T cell helper activity. The basic assumption underlying this approach is that allogeneic T cells can help B cells to differentiate into immunoglobulin-producing cells. , 1979). This lack of genetic restriction may reflect the fact, noted above, that T cells stimulated by PWM and certain other polyclonal activators secrete molecules that will induce B cells to differentiate into immunoglobulin-secreting cells.
Advances in Immunology, Vol. 32 by Frank J. (Editor) Dixon