Adrenal Actions on Brain by Bruce S. McEwen (auth.), Dr. Detlev Ganten M.D., Ph.D., Dr. PDF
By Bruce S. McEwen (auth.), Dr. Detlev Ganten M.D., Ph.D., Dr. Donald Pfaff Ph.D. (eds.)
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Tex Rep BioI Med 31 :271-293 de Vellis J, Schjeide OA, Clemente CD (1967) Protein synthesis and enzymic patterns in the developing brain following head X-irradiation of newborn rats. J Neurochem 14:499-511 de Vellis J, Inglish D, Cole R, Molson J (1971) Effects of hormones on the differentiation of cloned lines of neurons and glial cells. In: Ford E (ed) Influence of hormones on the nervous system. Karger, Basel, pp 25-39 de Vellis J, McEwen BS, Cole R, Inglish D (1974) Relations between glucocorticoid nuclear binding, cytosol receptor activity and enzyme induction in a rat glial cell line.
Acta Physiol Scand 66:253-254 Glucocorticoids and the Developing Nervous System 39 Eriinko 0, Eriinko L, Hill CE, Burnstock G (1972a) Hydrocortisone-induced increase in the number of small intensely fluorescent cells and their histochemically demonstrable catecholamine content in cultures of sympathetic ganglia of the newborn rat. Histochem J 4:49-58 Eriinko 0, Heath J, Eriinko L (1972b) Effect of hydrocortisone on the ultrastructure of the small, intensely fluorescent, granule-containing cells in cultures of sympathetic ganglia of newborn rat.
1973; Saavedra et al. 1974). Neonatal dexamethasone administration increases PNMT activity in both hypothalamus and brain stem, measured both acutely (Moore and Phillipson 1975) or later, in adult animals (Turner et al. 1979). In the latter case, PNMT activity was measured after 30 min of stress, so it is not yet clear if the elevation represents an exaggerated stress response or a permanent elevation in enzyme activity. It is not known if the PNMT increase in brain is due to an enhanced induction of the enzyme as in the adrenal and/or to hyperplasia of inducible PNMTcontaining cells as may be occurring in sympathetic ganglia.
Adrenal Actions on Brain by Bruce S. McEwen (auth.), Dr. Detlev Ganten M.D., Ph.D., Dr. Donald Pfaff Ph.D. (eds.)