Get A Systems Biology Approach to Blood PDF

By Seth Joel Corey, Marek Kimmel, Joshua N. Leonard

ISBN-10: 1493920944

ISBN-13: 9781493920945

ISBN-10: 1493920952

ISBN-13: 9781493920952

The blood process is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood involves circulating cells, mobile fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments outcome from a highly-ordered technique, hematopoiesis. Definitive hematopoiesis happens within the bone marrow, the place pluripotential stem cells provide upward thrust to a number of lineages of hugely really good cells. Highly-productive and regularly regenerative, hematopoiesis calls for a microenvironment of mesenchymal cells and blood vessels.

A platforms Biology method of Blood is split into 3 major sections: uncomplicated parts, physiological techniques, and scientific purposes. utilizing blood as a window, you'll be able to examine healthiness and disorder via this designated software field with reactive organic fluids that mirrors the existing hemodynamics of the vessel partitions and some of the blood phone kinds. Many blood illnesses, infrequent and customary can and feature been exploited utilizing structures biology methods with winning effects and for that reason excellent types for structures medication. extra importantly, hematopoiesis bargains the best studied platforms with perception into stem mobilephone biology, mobile interplay, improvement; linage programing and reprograming which are on a daily basis stimulated by means of the main mature and understood regulatory networks.

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Extra resources for A Systems Biology Approach to Blood

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Kokkaliaris KD, Loeffler D, Schroeder T. Advances in tracking hematopoiesis at the single-cell level. Curr Opin Hematol. 2012;19(4):243–9. 92. Schroeder T. Long-term single-cell imaging of mammalian stem cells. Nat Methods. 2011;8(4 Suppl):30–5. 93. Scherf N, Franke K, Glauche I, Kurth I, Bornhauser M, Werner C, et al. On the symmetry of siblings: automated single-cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup. Exp Hematol. 2012;40(2):119–30 e9. 94. Krinner A, Zscharnack M, Bader A, Drasdo D, Galle J.

71. Roeder I, Braesel K, Lorenz R, Loeffler M. Stem cell fate analysis revisited: interpretation of individual clone dynamics in the light of a new paradigm of stem cell organization. J Biomed Biotechnol. 2007;2007(3):84656. 72. Roeder I, Horn K, Sieburg HB, Cho R, Muller-Sieburg C, Loeffler M. Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach. Blood. 2008;112(13):4874–83. 73. Roeder I, Horn M, Glauche I, Hochhaus A, Mueller MC, Loeffler M.

Trentin JJ. Determination of bone marrow stem cell differentiation by stromal hemopoietic inductive microenvironments (HIM). Am J Pathol. 1971;65(3):621–8. 7. Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells. 1978;4(1–2):7–25. 8. Allen TD, Dexter TM. The essential cells of the hemopoietic microenvironment. Exp Hematol. 1984;12(7):517–21. 2 Quantification and Modeling of Stem Cell– Niche Interaction 33 9. Dexter TM, Wright EG, Krizsa F, Lajtha LG.

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A Systems Biology Approach to Blood by Seth Joel Corey, Marek Kimmel, Joshua N. Leonard

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