A Physical Theory of the Living State the - download pdf or read online
By Gilbert N Ling
Unique 1963 assessment by means of Jay Jacobs, MD:
A actual concept of the dwelling kingdom: The Association-Induction speculation. by way of GILBERT Ning LING, B.Sc., PH.D., Director of the dept of Molecular Biology, Pennsylvania Hospital.
Cloth, Pp. 680, with illustrations. Blaisdell Publishing Co.,A department of Random condo. Inc., long island, London, 1962.
The writer has been famous in his box for 15 years. His paintings is praised through his friends, together with Dr. C. N. Yang, a Nobel Laureate in Physics. This publication was once written to coordinate actual chemistry, biochemistry and body structure, and clarify many of the intricacies of dwelling tissue.
The contents are on such a sophisticated point that these acquainted with one element could be baflled through others. to assist in overcoming this trouble and to bridge the space among medical disciplines there's a thesaurus of seventy one pages.
Unfortunately, the mathematical calculations in a few parts are too advanced for someone who has no longer had really expert training.
The variety of topics is wide; habit of Ions, nonelectrolytes and proteins; mobile potentials and permeabillty; excitatton, contraction and inhibition; the activities or enzymes, hormones, and medication; progress and neoplasm. The author's "association-induction" speculation is drawn upon to give an explanation for the phenomena or chemical motion in residing tissue. This speculation states that the associatlon among proteins and interacting debris is significantly various in vivo and In vitro, and that the first functionality of the polarizable resonating chain of a protein is to supply a car for the transmission of an inductive effect.
The booklet comprises many tables, graphs, diagrams and mathematical calculations to help its theses. The bibliography and references are extensive.
Every health care provider may still learn a few parts of this e-book, to determine how a ways the elemental scientists have are available in realizing the habit of dwelling tissue. it's of price largely as a reference booklet to these whose paintings is on the easy technological know-how point.
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Additional info for A Physical Theory of the Living State the association-induction hypothesis
In compounds with longer alkyl chains, however, the nearly ideal behavior,* as shown by their equivalent conductances, breaks down abruptly at a critical concentration. A very sharp drop in equivalent conductance is associated with further increase of concentration. This phenomenon has been explained as a result of micelle formation (J. W. McBain, 1913; G. S. Hartley, 1936). The equivalent conductance is the sum of the conductances due to the anion and the cation. The fractions of current carried by the cation and the anion are called the transference numbers t+ and L; these are determined by the mobilities u+ and u_ and the ionic concentrations C+ and C_: t - C+u+ + - C+u+ C_u_ + (2 2) - t = C_u_ .
5. Summary 40 13 Association 14 The complex systems of protein, water, and ions that we call living matter are invariably found in environments of dilute aqueous salt solution, either as an external environment in the form of fresh or ocean water, or as an internal milieu in the form of tissue fluid. In the introduction, we argued that biological interactions must be determined by specific short-range forces in conjunction with long-range forces, rather than by the latter alone. Yet the most notable achievements in the understanding of dilute aqueous salt solutions (Debye and Ruckel, 1923; Bjerrum, 1926) are consistent with, and in fact demand that the interactions between ions in dilute solution be almost entirely due to long-range Coulombic forces.
The CUrVeS show the total equivalent conductance A. and the transport number of the paraffin chain cations t+ of cetylpyridinium • and cetyltrimethylammonium • bromides at 35°C. The inflection 1 marks the critical point for micelle formation with its associated charge fixation. Cationic transfer numbers were determined by the moving boundary method. (Figure after G. S. 3, agrees perfectly with this view. Similar dependence of the critical concentration of dodecyl sulfate on the nature of the alkali-metal countercation, K+, Na+, and so on, has also been reported by Meguro et al.
A Physical Theory of the Living State the association-induction hypothesis by Gilbert N Ling