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6 Nomenclature relative occupancy and isotropic temperature factor of the atom in the protein crystal, are not used by GRID. A valuable characteristic of PDB format is that so much relevant information can be condensed into about 60 characters at the start of a line. The rest of the line can then be used by GRID for all the other data which are needed to specify the properties of an atom. The input program GRIN prepares all this data automatically, and writes it at the end of the line after the first 60 characters.

Acknowledgment To print a list of the teachers and colleagues who have helped me would occupy too much space here. My debt to all of them is immense, and is only matched by my gratitude to each one for their generosity, and to my wife for all her support and encouragement. L. Pauling Z. Kryst. 1934, 87, 205–238. 2 P. J. Goodford J. Med. Chem. 1985, 28, 849–857. 3 G. Cruciani, K. A. Watson J. Med. Chem. 1994, 37, 2589–2601. 4 L. D. Landau, E. M. ), Pergamon Press, Oxford, 1960, Vol. 8. 5 D. N. A.

M. ), Pergamon Press, Oxford, 1960, Vol. 8. 5 D. N. A. Boobbyer, P. J. Goodford, P. M. McWhinnie, R. C. Wade J. Med. Chem. 1989, 36, 1083. 6 R. C. Wade, J. Clark, P. J. Goodford J. Med. Chem. 1993, 36, 140–147. 7 R. C. Wade, P. J. Goodford J. Med. Chem. 1993, 36, 148–156. 8 M. von Itzstein et al. Nature (London) 1993, 363, 418–423. 9 P. J. Goodford J. Chemometrics 1996, 10, 107–117. 10 T. Langer Quant. -Act. Relat. 1996, 15, 469–474. 11 A. Berglund; M. C. De Rosa, S. Wold J. Comput-Aided. Mol. Design 1997, 11, 601–612.

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2-very ampleness for adjoint bundles of ample and spanned vector bundles on surfaces by Lanteri A.


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